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Misoprostol dose and timing before surgical abortion at 13 to 16 weeks' gestation: A randomized trial

Gillian Dean, MD, MPH, Planned Parenthood of New York City, Inc.

Project abstract

We propose to conduct a blinded randomized trial to compare two different doses and intervals of buccal misoprostol for cervical preparation before surgical abortion at 13 to 16 weeks' gestation: 400 mcg administered 3 hours pre-operatively, and 600 mcg administered 1.5 hours pre-operatively. We plan to conduct the study using a non-inferiority design with the hypothesis that misoprostol at a higher dose over a shorter interval does not meaningfully increase operative time compared with a lower dose over a longer interval. We will investigate other outcomes, including cervical dilation, side effects, and patient and provider satisfaction.

The information gained from this study may have an impact on guidelines for cervical preparation before surgical abortion in the late first and early second trimester, and may help physicians choose the optimal dose and interval of misoprostol before surgical abortion.


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